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Copper-Catalyzed Asymmetric Reduction of 3,3-Diarylacrylonitriles

Daehyung Lee, Youngmin Yang and Jaesook Yun*

*Department of Chemistry and Institute of Basic Science, Sungkyunkwan University, Suwon 440-746, Korea, Email: jaesookskku.edu

D. Lee, Y. Yang, J. Yun, Org. Lett., 2007, 9, 2749-2751.

DOI: 10.1021/ol0712071 (free Supporting Information)


Abstract

A range of 3-aryl-3-pyridylacrylonitriles were reduced with high levels of enantioselectivity under optimal conditions employing a copper/Josiphos complex in the presence of polymethylhydrosiloxane (PMHS).

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Highly Enantioselective Conjugate Reduction of β,β-Disubstituted α,β-Unsaturated Nitriles

D. Lee, D. Kim, S. Yun, Angew. Chem. Int. Ed., 2006, 45, 2785-2787.


Key Words

Reduction of α,β-unsaturated compounds, PMHS, Copper Hydride


ID: J54-Y2007-2290