Easily Accessible and Highly Tunable Indolyl Phosphine Ligands for Suzuki-Miyaura Coupling of Aryl Chlorides
Chau Ming So, Chak Po Lau and Fuk Yee Kwong*
*Department of Applied Biology and Chemical Technology, The
Hong Kong Polytechnic University, Kowloon, Hong Kong, Email: bcfyk
inet.polyu.edu.hk
C. M. So, C. P. Lau, F. Y. Kwong, Org. Lett., 2007, 9, 2795-2798.
DOI: 10.1021/ol070898y (free Supporting Information)
Abstract
A new class of easily accessible indolyl phosphine ligands provides high potential of steric and electronic tunability. The air-stable indolyl phosphines in combination with a palladium metal precursor are effective catalysts for Suzuki-Miyaura coupling of unactivated aryl chlorides, and a catalyst loading down to 0.02 mol % can be achieved.
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ID: J54-Y2007-2380
