Tetrazolic Acid Functionalized Dihydroindol: Rational Design of a Highly Selective Cyclopropanation Organocatalyst
Antti Hartikka and Per I. Arvidsson*
*Department of Biochemistry and Organic Chemistry, Uppsala
University, Box 576, SE-75123 Uppsala, Sweden, Email: per.arvidsson
biorg.uu.se
A. Hartikka, P. I. Arvidsson, J. Org. Chem., 2007, 72, 5874-5877.
DOI: 10.1021/jo070519e
Abstract
(S)-(-)-indoline-2-yl-1H-tetrazole readily facilitates the enantioselective organocatalytic cyclopropanation of α,β-unsaturated aldehydes with sulfur ylides, providing cyclized product in excellent diastereoselectivities and enantioselectivities.
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Key Words
Corey-Chaykovsky Reaction, Cyclopropanes, Organocatalysis
ID: J42-Y2007-2380
