Indium(III) Trifluoromethanesulfonate as an Efficient Catalyst for the Deprotection of Acetals and Ketals
Brian T. Gregg,* Kathryn C. Golden and John F. Quinn
*Department of Medicinal Chemistry, AMRI, Albany, New York
12203, Email: brian.gregg
amriglobal.com
B. T. Gregg, K. C. Golden, J. F. Quinn, J. Org. Chem., 2007, 72, 5890-5893.
DOI: 10.1021/jo0707075 (free Supporting Information)
Abstract
Acetals and ketals are readily deprotected under neutral conditions in the presence of acetone and indium(III) trifluoromethanesulfonate as catalyst at room temperature or mild microwave heating conditions to give the corresponding aldehydes and ketones in good to excellent yields.
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Key Words
deprotection of acetals, cyclic acetals, dimethyl acetals, microwave synthesis
ID: J42-Y2007-2400
