Comparison of Ru- and Mo-Based Chiral Olefin Metathesis Catalysts. Complementarity in Asymmetric Ring-Opening/Cross-Metathesis Reactions of Oxa- and Azabicycles
G. Alex Cortez, Carl A. Baxter, Richard R. Schrock and Amir H. Hoveyda*
*Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, Email: amir.hoveydabc.edu
G. A. Cortez, C. A. Baxter, R. R. Schrock, A. H. Hoveyda, Org. Lett., 2007, 9, 2871-2874.
DOI: 10.1021/ol071008h (free Supporting Information)
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A comparative study of chiral Mo- and Ru-based catalysts to promote enantioselective synthesis of 2,6-disubstituted pyrans and piperidines through asymmetric ring-opening/cross-metathesis reactions demonstrated the critical complementarity that exists between the two classes of chiral catalysts.
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