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Comparison of Ru- and Mo-Based Chiral Olefin Metathesis Catalysts. Complementarity in Asymmetric Ring-Opening/Cross-Metathesis Reactions of Oxa- and Azabicycles

G. Alex Cortez, Carl A. Baxter, Richard R. Schrock and Amir H. Hoveyda*

*Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, Email: amir.hoveydabc.edu

G. A. Cortez, C. A. Baxter, R. R. Schrock, A. H. Hoveyda, Org. Lett., 2007, 9, 2871-2874.

DOI: 10.1021/ol071008h (free Supporting Information)



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Abstract

A comparative study of chiral Mo- and Ru-based catalysts to promote enantioselective synthesis of 2,6-disubstituted pyrans and piperidines through asymmetric ring-opening/cross-metathesis reactions demonstrated the critical complementarity that exists between the two classes of chiral catalysts.

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Key Words

Ring Opening Metathesis, Tetrahydropyrans


ID: J54-Y2007-2450