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Direct Use of Allylic Alcohols for Platinum-Catalyzed Monoallylation of Amines

Masaru Utsunomiya, Yoshiki Miyamoto, Junji Ipposhi, Takashi Ohshima* and Kazushi Mashima*

*Department of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan, Email: ohshimachem.es.osaka-u.ac.jp, mashimachem.es.osaka-u.ac.jp

M. Utsunomiya, Y. Miyamoto, J. Ipposhi, T. Ohshima, K. Mashima, Org. Lett., 2007, 9, 3371-3374.

DOI: 10.1021/ol071365s (free Supporting Information)


Abstract

A direct catalytic amination of allylic alcohols without the use of activating reagents is promoted by the combination of platinum and the large bite-angle ligand DPEphos. The use of the DPEphos ligand was essential for obtaining high catalyst activity and high monoallylation selectivity of primary amines, allowing the formation of various monoallylated products in good yield.

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Key Words

Allylic Amines


ID: J54-Y2007-2700