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Pd-C-Induced Catalytic Transfer Hydrogenation with Triethylsilane

Pijus K. Mandal and John S. McMurray*

*Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030, Email: jsmcmurmdanderson.org

P. K. Mandal, J. S. McMurray, J. Org. Chem., 2007, 72, 6599-6601.

DOI: 10.1021/jo0706123 (free Supporting Information)


Abstract

In situ generation of molecular hydrogen by addition of triethylsilane to palladium on charcoal results in rapid and efficient reduction of multiple bonds, azides, imines, and nitro groups, as well as deprotection of benzyl and allyl groups under mild, neutral conditions.

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Key Words

Reduction (Alkenes, Alkynes), Benzyl Esters, Benzyl Ethers, Benzyl Carbamates, Triethylsilane


ID: J42-Y2007-2710