Organic Chemistry Portal

Abstracts

Search:

Practical Asymmetric Henry Reaction Catalyzed by a Chiral Diamine-Cu(OAc)2 Complex

Takayoshi Arai,* Masahiko Watanabe and Akira Yanagisawa

*Department of Chemistry, Graduate School of Science, Chiba University, Inage 263-8522, Japan, Email: taraifaculty.chiba-u.jp

T. Arai, M. Watanabe, A. Yanagisawa, Org. Lett., 2007, 9, 3595-3597.

DOI: 10.1021/ol7014362 (free Supporting Information)


Abstract

A complex of a chiral diamine ligand and Cu(OAc)2 was a highly efficient catalyst for the Henry reaction, giving various nitroaldols with with over 90% ee. The reaction was performed in n-propyl alcohol at room temperature, and the Henry adducts were produced in high yield with excellent enantiomeric excess.

see article for more examples



Key Words

Henry Reaction


ID: J54-Y2007-2810