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Effect of Lithium Chloride on Tuning the Reactivity of Pauson-Khand Reactions Catalyzed by Palladium-Tetramethylthiourea

Lu-Jiang Deng, Jing Liu, Ji-Qing Huang, Yanhe Hud, Mao Chen, Yu Lan, Jia-Hua Chen, Aiwen Lei, Zhen Yang*

*State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing 100871, P. R. of China, Email: zyangpku.edu.cn

L.-J. Deng, J. Liu, J.-Q. Huang, Y. Hud, M. Chen, Y. Lan, J.-H. Chen, A. Lei, Z. Yang, Synthesis, 2007, 2565-2570.

DOI: 10.1055/s-2007-983796


Abstract

A general and robust transition-metal-catalyzed Pauson-Khand reaction is achieved in the presence of lithium chloride. The effect of lithium chloride on Pauson-Khand reactions catalyzed by palladium(II) chloride-tetra­methylthiourea allows the efficient preparation of structurally diverse cyclopentenones.


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Key Words

cyclizations, enynes, lithium chloride, Pauson-Khand Reaction, transition-metal catalysis


ID: J66-Y2007-2840