Effect of Lithium Chloride on Tuning the Reactivity of Pauson-Khand Reactions Catalyzed by Palladium-Tetramethylthiourea
Lu-Jiang Deng, Jing Liu, Ji-Qing Huang, Yanhe Hud, Mao Chen, Yu Lan, Jia-Hua Chen, Aiwen Lei, Zhen Yang*
*State Key Laboratory of Natural and Biomimetic Drugs, School
of Pharmaceutical Science, Peking University, Beijing 100871, P. R. of China, Email:
zyang
pku.edu.cn
L.-J. Deng, J. Liu, J.-Q. Huang, Y. Hud, M. Chen, Y. Lan, J.-H. Chen, A. Lei, Z. Yang, Synthesis, 2007, 2565-2570.
Abstract
A general and robust transition-metal-catalyzed Pauson-Khand reaction is achieved in the presence of lithium chloride. The effect of lithium chloride on Pauson-Khand reactions catalyzed by palladium(II) chloride-tetramethylthiourea allows the efficient preparation of structurally diverse cyclopentenones.
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Key Words
cyclizations, enynes, lithium chloride, Pauson-Khand Reaction, transition-metal catalysis
ID: J66-Y2007-2840
