Organic Chemistry Portal

Abstracts

Search:

A Novel Practical Synthesis of Benzothiazoles via Pd-Catalyzed Thiol Cross-Coupling

Takahiro Itoh* and Toshiaki Mase

*Merck Research Laboratories, Merck & Co., Inc., RY50G-132, 126 East Lincoln Avenue, P.O. Box 2000, Rahway NJ 07065-0900, Email: takahiro_itohmerck.com

T. Itoh, T. Mase, Org. Lett., 2007, 9, 3687-3689.

DOI: 10.1021/ol7015737 (free Supporting Information)


Abstract

Various 2-bromoanilides were reacted with 2-ethylhexyl 3-mercaptopropionate in high yields using a palladium catalyst. Subsequent generation of thiols and condensation under basic or acidic conditions allows a convenient synthesis of substituted benzothiazoles.

see article for more examples



Key Words

Benzothiazoles


ID: J54-Y2007-2910