A Novel Practical Synthesis of Benzothiazoles via Pd-Catalyzed Thiol Cross-Coupling
Takahiro Itoh* and Toshiaki Mase
*Merck Research Laboratories, Merck & Co., Inc., RY50G-132,
126 East Lincoln Avenue, P.O. Box 2000, Rahway NJ 07065-0900, Email: takahiro_itoh
merck.com
T. Itoh, T. Mase, Org. Lett., 2007, 9, 3687-3689.
DOI: 10.1021/ol7015737
Abstract
Various 2-bromoanilides were reacted with 2-ethylhexyl 3-mercaptopropionate in high yields using a palladium catalyst. Subsequent generation of thiols and condensation under basic or acidic conditions allows a convenient synthesis of substituted benzothiazoles.
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Key Words
ID: J54-Y2007-2910
