An Efficient, Inexpensive and Shelf-Stable Diazotransfer Reagent: Imidazole-1-sulfonyl Azide Hydrochloride
Ethan D. Goddard-Borger* and Robert V. Stick
*Chemistry M313, School of Biomedical, Biomolecular &
Chemical Sciences, The University of Western Australia, Crawley WA 6009,
Australia, Email: goddae01
student.uwa.edu.au
E. D. Goddard-Borger, R. V. Stick, Org. Lett., 2007, 9, 3797-3800.
DOI: 10.1021/ol701581g (free Supporting Information)
see article for more reactions
Abstract
Imidazole-1-sulfonyl azide hydrochloride equals triflyl azide in its ability to act as a “diazo donor” in the conversion of both primary amines into azides and activated methylene substrates into diazo compounds. Crucially, this reagent can be prepared in a one-pot reaction on a large scale from inexpensive materials, is shelf-stable and is conveniently crystalline.
see article for more examples
Key Words
ID: J54-Y2007-2980
