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Design of Organocatalysts for Asymmetric Direct Syn-Aldol Reactions

Xiao-Ying Xu, Yan-Zhao Wang and Liu-Zhu Gong*

*Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China, Email: gonglzustc.edu.cn

X.-Y. Xu, Y.-Z. Wang, L.-Z. Gong, Org. Lett., 2007, 9, 4247-4249.

DOI: 10.1021/ol701798x (free Supporting Information)



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Abstract

Organocatalysts derived from l-leucine and l-valine afforded the direct syn-aldol reactions of a wide scope of aldehydes with various ketones with excellent diastereomeric ratios and enantioselectivities.

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Key Words

Aldol Addition, Organocatalysis


ID: J54-Y2007-3210