Copper-Catalyzed Asymmetric N-H Insertion Reactions: Couplings of Diazo Compounds with Carbamates to Generate α-Amino Acids
Elaine C. Lee and Gregory C. Fu*
*Department of Chemistry, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139, Email: gcf
mit.edu
E. C. Lee, G. C. Fu, J. Am. Chem. Soc., 2007, 129, 12066-12067.
DOI: 10.1021/ja074483j
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Abstract
A new Cu/chiral bipyridine catalyst for the asymmetric insertion of α-diazocarbonyl compounds into the N-H bonds of carbamates generate an array of easily deprotected arylglycines in good ee.
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Key Words
ID: J48-Y2007-3230
