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A new one-step synthesis of pyridines under microwave-assisted conditions

Mark C. Bagley*, Rebecca Lunn and Xin Xiong

*Department of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK, Email: bagleymccf.ac.uk

M. C. Bagley, R. Lunn, X. Xiong, Tetrahedron Lett., 2002, 43, 8331-8334.

DOI: 10.1016/S0040-4039(02)01975-5


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Abstract

Tri- or tetrasubstituted pyridines are prepared by microwave irradiation of ethyl β-aminocrotonate and various alkynones in a single synthetic step and with total control of regiochemistry. This new one-pot Bohlmann-Rahtz procedure conducted at 170C gives superior yields to similar experiments conducted using conductive-heating techniques in a sealed tube.

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A new mild method for the one-pot synthesis of pyridines

X. Xiong, M. C. Bagley, K. Chapaneri, Tetrahedron Lett., 2004, 45, 6121-6124.

A New Modification of the Bohlmann-Rahtz Pyridine Synthesis

M. C. Bagley, J. W. Dale, J. Bower, Synlett, 2001, 1149-1151.


Key Words

pyridines, microwave synthesis, Bohlmann-Rahtz Pyridine Synthesis


ID: J72-Y2002-1790