Gold-Catalyzed Multicomponent Synthesis of Aminoindolizines from Aldehydes, Amines, and Alkynes under Solvent-Free Conditions or in Water

Bin Yan and Yuanhong Liu*

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China, Email: yhliumail.sioc.ac.cn

B. Yan, Y. Liu, Org. Lett., 2007, 9, 4323-4326.

DOI: 10.1021/ol701886e (free Supporting Information)

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Abstract

A gold(III)-catalyzed multicomponent coupling/cycloisomerization reaction of heteroaryl aldehydes, amines, and alkynes under solvent-free conditions or in water provides rapid access to substituted aminoindolizines with high atom economy and high catalytic efficiency.

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proposed mechanism

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General and Direct Synthesis of 3-Aminoindolizines and Their Analogues via Pd/Cu-Catalyzed Sequential Cross-Coupling/Cycloisomerization Reactions

Y. Liu, Z. Song, B. Yan, Org. Lett., 2007, 9, 409-412.

Highly Efficient Synthesis of Functionalized Indolizines and Indolizinones by Copper-Catalyzed Cycloisomerizations of Propargylic Pyridines

B. Yan, Y. Zhou, H. Zhang, J. Chen, Y. Liu, J. Org. Chem., 2007, 72, 7783-7786.

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Key Words

Indolizines, Multicomponent Reactions, Green Chemistry

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ID: J54-Y2007-3250