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Ir-Catalyzed Regio- and Enantioselective Decarboxylative Allylic Alkylations

Hu He, Xiao-Jian Zheng, Yi Li, Li-Xin Dai and Shu-Li You*

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China, Email: slyoumail.sioc.ac.cn

H. He, X.-J. Zheng, Y. Li, L.-X. Dai, S.-L. You, Org. Lett., 2007, 9, 4339-4341.

DOI: 10.1021/ol7019394


Abstract

A combination of [Ir(COD)Cl]2 and a phosphoramidite ligand is an efficient catalytic system for a highly regio- and enantioselective decarboxylative alkylation of γ-substituted allyl β-ketocarboxylates, affording branched products with a regioselectivity of up to 99:1 and 96% ee.

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Key Words

Allylation


ID: J54-Y2007-3280