Superior Effect of a π-Acceptor Ligand (Phosphine−Electron-Deficient Olefin Ligand) in the Negishi Coupling Involving Alkylzinc Reagents
Xiancai Luo, Heng Zhang, Hui Duan, Qiang Liu, Lizheng Zhu, Tony Zhang and Aiwen Lei*
*College of Chemistry and Molecular Sciences, Wuhan University, PR China, Email: aiwenleiwhu.edu.cn
X. Luo, H. Zhang, H. Duan, Q. Liu, L. Zhu, T. Zhang, A. Lei, Org. Lett., 2007, 9, 4571-4574.
DOI: 10.1021/ol701995t (free Supporting Information)
Palladium-catalyzed Negishi cross-coupling involving primary and secondary alkyls, even in the presence of β-H, can be achieved using chelating phosphine ligands containing an electron-deficient olefin. The superior effects of the ligands were shown not only in the desired cross-coupling product yields but also in the fast reaction at mild conditions.
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