Highly Selective Rhodium-Catalyzed Conjugate Addition Reactions of 4-Oxobutenamides
Jamie L. Zigterman, Jacqueline C. S. Woo, Shawn D. Walker, Jason S. Tedrow,* Christopher J. Borths, Emilio E. Bunel and Margaret M. Faul
*Chemical Process Research and Development, Amgen Inc.,
Thousand Oaks, California 91320-1799, Email: jtedrow
amgen.com
J. L. Zigterman, J. C. S. Woo, S. D. Walker, J. S. Tedrow, C. J. Borths, E. E. Bunel, M. M. Faul, J. Org. Chem., 2007, 72, 8870-8876.
DOI: 10.1021/jo701682c (free Supporting Information)
Abstract
Rhodium-catalyzed conjugate addition of arylboronic acids to various 4-oxobutenamides provides oxobutanamides with high regio- and enantioselectivity and good yields in the presence of sterically demanding P-chiral diphosphines, such as Tangphos or Duanphos.
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ID: J42-Y2007-3560
