Rh(II)-Catalyzed Intermolecular Oxidative Sulfamidation of Aldehydes: A Mild Efficient Synthesis of N-Sulfonylcarboxamides
Johann Chan,* Kyle D. Baucom and Jerry A. Murry
*Chemical Process Research and Development, Amgen Inc., Thousand Oaks, California 91320, Email: johanncamgen.com
J. Chan, K. D. Baucom, J. A. Murry, J. Am. Chem. Soc., 2007, 129, 14106-14107.
DOI: 10.1021/ja073872a (free Supporting Information)
A Rh(II)-catalyzed oxidative coupling of aldehydes and sulfonamides provides N-sulfonylcarboxamides in one step. Various sulfonamides were found to react with aromatic and aliphatic aldehydes to afford the desired products in very good yields.
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