Coupling Reaction of Alkyl Chlorides with Silyl Enolates Catalyzed by Indium Trihalide
Yoshihiro Nishimoto, Makoto Yasuda and Akio Baba*
*Department of Applied Chemistry, Center for Atomic and
Molecular Technologies (CAMT), Graduate School of Engineering, Osaka University,
2-1 Yamadaoka, Suita, Osaka 565-0871, Japan, Email: baba
chem.eng.osaka-u.ac.jp
Y. Nishimoto, M. Yasuda, A. Baba, Org. Lett., 2007, 9, 4931-4934.
DOI: 10.1021/ol701684n (free Supporting Information)
Abstract
Indium(III) halide catalyzed the coupling of alkyl chlorides with silyl enolates derived from esters, ketones, and aldehydes to give various α-alkylated carbonyl compounds. A one-pot, three-component reactions of aldehyde enolates, alkyl chlorides, and allylsilanes or alkynylsilanes is described.
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Key Words
Carbonyl Compounds, Carboxylic Acid Derivatives
ID: J54-Y2007-3650
