Preparation of Mono-, Di-, and Trisubstituted Ureas by Carbonylation of Aliphatic Amines with S,S-Dimethyl Dithiocarbonate
Emma Artuso, Iacopo Degani, Rita Fochi*, Claudio Magistris
*Dipartimento di Chimica Generale ed Organica Applicata
dell'Università, Università degli Studi di Torino, C. so M. D'Azeglio 48, 10125
Torino, Italy,
Email: rita.fochi
unito.it
E. Artuso, I. Degani, R. Fochi, C. Magistris, Synthesis, 2007, 3497-3506.
Abstract
General procedures allow the carbonylation of aliphatic amines by employing S,S-dimethyl dithiocarbonate (DMDTC) as a phosgene substitute to yield N-alkylureas, N,N′-dialkylureas (both symmetrical and unsymmetrical), and N,N,N′-trialkylureas. All reactions were carried out in water.
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Key Words
ureas, carbonylation, amines, dithiocarbonates, thiocarbamates, green chemistry
ID: J66-Y2007-3690
