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A Simple and Efficient Procedure of Low Valent Iron- or Copper-Mediated Reformatsky Reaction of Aldehydes

Angshuman Chattopadhyay* and Akhil Kr. Dubey

*Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai-400 085, India, Email: achatapsara.barc.ernet.in

A. Chattopadhyay, A. Kr. Dubey, J. Org. Chem., 2007, 72, 9357-9359.

DOI: 10.1021/jo0710984 (free Supporting Information)


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Abstract

An operationally simple and very efficient Reformatsky reaction of aldehydes has been carried out in THF in the presence of low valent iron or copper which were prepared in situ employing a bimetal redox strategy through reduction of Fe(III) or Cu(II) salts with magnesium.

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Key Words

Reformatsky Reaction, magnesium, low valent iron


ID: J42-Y2007-3730