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Oppenauer Oxidation of Secondary Alcohols with 1,1,1-Trifluoroacetone as Hydride Acceptor

Rossella Mello, Jaime Martínez-Ferrer, Gregorio Asensio* and María Elena González-Núñez

*Departamento de Química Orgánica, Universidad de Valencia, Avda. V. Andrés Estellés s/n, 46100-Burjassot (Valencia), Spain, Email: gregorio.asensiouv.es

R. Mello, J. Martínze-Ferrer, G. Asensio, M. E. González-Núñez, J. Org. Chem., 2007, 72, 9376-9378.

DOI: 10.1021/jo7016422 (free Supporting Information)


Abstract

1,1,1-Trifluoroacetone can be used as a hydride-acceptor in the Oppenauer oxidation of secondary alcohols in the presence of diethylethoxyaluminum. The oxidant enables a selective oxidation of secondary alcohols in the presence of primary alcohols.

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Key Words

Openauer Oxidation, Ketones, Trifluoroacetone


ID: J42-Y2007-3780