Diphenylprolinol Silyl Ether as Catalyst of an Asymmetric, Catalytic, and Direct Michael Reaction of Nitroalkanes with α,β-Unsaturated Aldehydes
Hiroaki Gotoh, Hayato Ishikawa and Yujiro Hayashi*
*Department of Industrial Chemistry, Faculty of Engineering,
Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan, Email:
hayashi
ci.kagu.tus.ac.jp
H. Gotoh, H. Ishikawa, Y. Hayashi, Org. Lett., 2007, 9, 5307-5309.
DOI: 10.1021/ol702545z (free Supporting Information)
Abstract
A catalytic enantioselective direct conjugate addition of nitroalkanes to α,β-unsaturated aldehydes using diphenylprolinol silyl ether as an organocatalyst enables short syntheses of therapeutically useful compounds.
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Key Words
Nitro Compounds, Carbonyl Compounds
ID: J54-Y2007-4050
