Ruthenium-Catalyzed Cycloaddition of Aryl Azides and Alkynes
Lars Kyhn Rasmussen, Brant C. Boren and Valery V. Fokin*
*Department of Chemistry, The Scripps Research Institute,
10550 North Torrey Pines Road, La Jolla, California 92037, Email: fokin
scripps.edu
L. K. Rasmussen, B. C. Boren, V. V. Fokin, Org. Lett., 2007, 9, 5337-5339.
DOI: 10.1021/ol701912s (free Supporting Information)
Abstract
The formation of 1,5-disubstituted 1,2,3-triazoles from aryl azides and alkynes was readily accomplished using [Cp*RuCl]4 as catalyst in dimethylformamide. The reaction provided higher yields, cleaner product, and shorter reaction times when carried out under microwave irradiation.
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Key Words
ID: J54-Y2007-4080
