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gem-Dibromomethylarenes: A Convenient Substitute for Noncommercial Aldehydes in the Knoevenagel−Doebner Reaction for the Synthesis of α,β-Unsaturated Carboxylic Acids

John Kallikat Augustine,* Yanjerappa Arthoba Naik, Ashis Baran Mandal, Nagaraja Chowdappa and Vinuthan B. Praveen

*Syngene International Ltd., Biocon Park, Plot Nos. 2 and 3, Bommasandra IV Phase, Jigani Link Road, Bangalore-560 100, India, Email:

J. K. Augustine, Y. A. Naik, A. B. Mandal, N. Chowdappa, V. B. Praveen, J. Org. Chem., 2007, 72, 9854-9856.

DOI: 10.1021/jo701888m (free Supporting Information)


gem-Dibromomethylarenes are employed as stable and readily accessible aldehyde equivalents in an efficient Knoevenagel-Doebner reaction with malonic acid to yield α,β-unsaturated carboxylic acids.

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Key Words

Knoevenagel Condensation, Unsatured Carboxylic Acids

ID: J42-Y2007-4110