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Facile Access to Pyrazolines via Domino Reaction of the Huisgen Zwitterions with Aziridines

Sun-Liang Cui, Jing Wang and Yan-Guang Wang*

*Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China, Email: orgwygzju.edu.cn

S.-L. Cui, J. Wang, Y.-G. Wang, Org. Lett., 2008, 10, 13-16.

DOI: 10.1021/ol7022888 (free Supporting Information)


Abstract

A novel, efficient, and general domino reaction of 2-acylaziridines with the Huisgen zwitterions furnishes 2-pyrazolines. A possible mechanism for the domino sequence is proposed.

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Key Words

Pyrazolines, Aziridines, Triphenylphosphine


ID: J54-Y2008-0020