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(BDP)CuH: A “Hot” Stryker's Reagent for Use in Achiral Conjugate Reductions

Benjamin A. Baker, Žarko V. Bošković and Bruce H. Lipshutz*

*Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, Email: lipshutzchem.ucsb.edu

B. A. Baker, Ž. V. Bošković, B. H. Lipshutz, Org. Lett., 2008, 10, 289-292.

DOI: 10.1021/ol702689v (free Supporting Information)


Abstract

A ligand-modified, economical version of Stryker's reagent is based on a bidentate, achiral bis-phosphine. Generated in situ, “(BDP)CuH” smoothly effects conjugate reductions of a variety of unsaturated substrates, including those that are normally unreactive toward Stryker's reagent.

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Key Words

Conjugate Reduction, Copper Hydride, PMHS


ID: J54-Y2008-0190