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An Efficient Silane-Promoted Nickel-Catalyzed Amination of Aryl and Heteroaryl Chlorides

Georg Manolikakes, Andrei Gavryushin and Paul Knochel*

*Department Chemie und Biochemie, Ludwig-Maximilians-Universitšt, Butenandtstrasse 5-13, 81377 Munich, Germany, Email: knochcup.uni-muenchen.de

G. Manolikakes, A. Gavryushin, P. Knochel, J. Org. Chem., 2008, 73, 1429-1434.

DOI: 10.1021/jo702219f (free Supporting Information)


Abstract

A silane-promoted nickel-catalyzed amination of aryl chlorides with a catalytic amount of Ni(acac)2 and 3,5,6,8-tetrabromo-1,10-phenanthroline as ligand in the presence of polymethylhydrosiloxane gives the desired (het)arylamines in good yields. The reaction is sensitive to the nature and amount of the silane promoter.

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Key Words

Amination, PMHS


ID: J42-Y2008-0390