Organic Chemistry Portal

Abstracts

Search:

Preparation of α-Bromoacrylates: One-Pot Procedure for the Synthesis of Conjugated Acetylenic Carboxylates from Aldehydes with Ph3P/Br3CCO2Et

Joong-Gon Kim, Dong Ho Kang, Doo Ok Jang*

*Center for Bioactive Molecular Hybrids, Yonsei University, Seoul 120749, Korea, Email: dojangyonsei.ac.kr

J.-G. Kim, D. H. Kang, D. O. Jang, Synlett, 2008, 443-447.

DOI: 10.1055/s-2008-1032070


Abstract

Optimized conditions for the Wittig reaction of aldehydes with ethyl tribromoacetate and triphenylphosphine allowed the synthesis of α-bromoacrylates with high selectivity. A simple and efficient one-pot procedure was developed for the preparation of various conjugated acetylenic carboxylates in good yields.


see article for more examples



Key Words

unsaturated esters, alkynes, Wittig Reaction


ID: J60-Y2008-0460