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Efficient 1,2-Addition of Aryl- and Alkenylboronic Acids to Aldehydes Catalyzed by the Palladium/Thioether-Imidazolinium Chloride System

Masami Kuriyama,* Rumiko Shimazawa and Ryuichi Shirai*

*Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyoto 610-0395, Email: mkuriyamdwc.doshisha.ac.jp, rshiraidwc.doshisha.ac.jp

M. Kuriyama, R. Shimazawa, R. Shirai, J. Org. Chem., 2008, 73, 1597-1600.

DOI: 10.1021/jo7020983 (free Supporting Information)


Abstract

The use of a thioether-imidazolinium chloride as a heterobidentate carbene ligand precursor led to a high level of catalyst performance in the palladium-catalyzed 1,2-addition of aryl-, heteroaryl-, and alkenylboronic acids to aromatic, heteroaromatic, and aliphatic aldehydes.

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Key Words

Benzylic Alcohols, Allylic Alcohols


ID: J42-Y2008-0490