Strontium-Catalyzed Highly Enantioselective Michael Additions of Malonates to Enones
Magno Agostinho and Shū Kobayashi*
*Department of Chemistry, School of Science and Graduate
School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division,
ERATO, JST, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email: shu_kobayashi
chem.s.u-tokyo.ac.jp
M. Agostinho, S. Kobayashi, J. Am. Chem. Soc., 2008, 130, 2430-2431.
DOI: 10.1021/ja710332h
Abstract
A chiral strontium complex promotes the catalytic asymmetric Michael addition reactions of malonates to enones at room temperature, to afford the desired adducts in high yields and excellent enantioselectivities. This method provides an efficient approach to building blocks possessing various functional groups and possible sites for further functionalization.
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Key Words
Active Methylenes, Michael Addition
ID: J48-Y2008-0500
