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Nickel-Catalyzed Asymmetric Negishi Cross-Couplings of Secondary Allylic Chlorides with Alkylzincs

Sunghee Son and Gregory C. Fu*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

S. Son, G. C. Fu, J. Am. Chem. Soc., 2008, 130, 2756-2757.

DOI: 10.1021/ja800103z (free Supporting Information)


An effective nickel/Pybox catalyst for regioselective asymmetric Negishi cross-couplings of racemic secondary allylic chlorides with readily available organozinc halides has been developed.

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Nickel-Catalyzed Asymmetric Cross-Couplings of Racemic Propargylic Halides with Arylzinc Reagents

S. W. Smith, G. C. Fu, J. Am. Chem. Soc., 2008, 130, 12645-12647.

Key Words

Allylation, Negishi Coupling

ID: J48-Y2008-0560