Scope of Aminomethylations via Suzuki-Miyaura Cross-Coupling of Organotrifluoroborates
Gary A. Molander,* Paul E. Gormisky and Deidre L. Sandrock
*Roy and Diana Vagelos Laboratories, Department of Chemistry,
University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, Email:
gmolandr
sas.upenn.edu
G. A. Molander, P. E. Gormisky, D. L. Sandrock, J. Org. Chem., 2008, 73, 2052-2057.
DOI: 10.1021/jo800183q (free Supporting Information)
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Abstract
Scope and limitations of the Suzuki-Miyaura reaction of N,N-dialkylaminomethyltrifluoroborates with aryl halides were investigated. Aryl chlorides, iodides, and triflates coupled in good to excellent yields to give N,N-dialkylbenzylic amines.
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Key Words
ID: J42-Y2008-0650
