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Novel One-Pot, Three-Component Synthesis of New 2-Alkyl-5-aryl-(1H)-pyrrole-4-ol in Water

Behzad Khalili, Pedram Jajarmi, Bagher Eftekhari-Sis and Mohammed M. Hashemi*

*Department of Chemistry, Sharif University of Technology, P.O. Box 11365-9516, Tehran, Iran, Email: mhashemisharif.ir

B. Khalili, P. Jajarmi, B. Eftekhari-Sis, M. M. Hashemi, J. Org. Chem., 2008, 73, 2090-2095.

DOI: 10.1021/jo702385n (free Supporting Information)


Abstract

Various 2-alkyl-5-aryl-(1H)-pyrrole-4-ol derivatives were synthesized via a multicomponent reaction of β-dicarbonyl compounds with arylglyoxals in the presence of ammonium acetate in water at room temperature.

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Key Words

Pyrroles, Multicomponent Reactions, Green Chemistry


ID: J42-Y2008-0690