Indium(III) Trifluoromethanesulfonate: An Efficient Reusable Catalyst for the Alkynylation-Cyclization of 2-Aminoaryl Ketones and Synthesis of 2,4-Disubstituted Quinolines

Kushal C. Lekhok, Dipak Prajapati*, Ramesh C. Boruah

*Department of Medicinal Chemistry, North East Institute of Science & Technology, Jorhat 785 006, Assam, India, Email: dr_dprajapati2003yahoo.co.uk

K. C. Lekhok, D. Prajapati, R. C. Boruah, Synlett, 2008, 655-658.

DOI: 10.1055/s-2008-1042800

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Abstract

An environmentally friendly and highly efficient procedure gives 2,4-disubstituted quinoline derivatives by a simple alkynylation-cyclization reaction of 2-aminoaryl ketones with phenylacetylenes in the presence of indium(III) trifluoromethanesulfonate In(OTf)₃ under microwave irradiation and solvent-free conditions. The catalyst can be reused.

see article for more examples

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Ionic Liquid - an Efficient Recyclable System for the Synthesis of 2,4-Disubstituted Quinolines via Meyer-Schuster Rearrangement

R. Sarma, D. Prajapati, Synlett, 2008, 3001-3005.

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Key Words

2,4-disubstituted quinolines, quinolines, solvent-free conditions, microwave synthesis, indium triflate

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ID: J60-Y2008-0730