Highly Enantioselective Dynamic Kinetic Resolution of 1,2-Diarylethanols by a Lipase-Ruthenium Couple
Mahn-Joo Kim,* Yoon Kyung Choi, Sol Kim, Daeho Kim, Kiwon Han, Soo-Byung Ko and Jaiwook Park*
*Department of Chemistry, Pohang University of Science and
Technology (POSTECH), San-31 Hyojadong, Pohang 790-784, Korea, Email: mjkim
postech.ac.kr,
pjwpostech.ac.kr
M.-J. Kim, Y. K. Choi, S. Kim, D. Kim, K. Han, S.-B. Ko, J. Park, Org. Lett., 2008, 10, 1295-1298.
DOI: 10.1021/ol800163z
Abstract
A practical procedure has been developed for the dynamic kinetic resolution of 1,2-diarylethanols using a highly enantioselective lipase from Pseudomonas stutzeri as the resolution catalyst and a ruthenium complex as the racemization catalyst. Various 1,2-diarylethanols have been efficiently resolved to provide their acetyl derivatives with good yields and high enantiomeric excesses.
see article for more examples
Dynamic Kinetic Resolution of Allylic Alcohols Mediated by Ruthenium- and Lipase-Based Catalysts
D. Lee, E. A. Huh, M.-J. Kim, H. M. Jung, J. H. Koh, J. Park, Org. Lett., 2000, 2, 2377-2379.
Key Words
kinetic resolution of alcohols
ID: J54-Y2008-0800
