Highly Enantioselective Dynamic Kinetic Resolution of 1,2-Diarylethanols by a Lipase-Ruthenium Couple
Mahn-Joo Kim,* Yoon Kyung Choi, Sol Kim, Daeho Kim, Kiwon Han, Soo-Byung Ko and Jaiwook Park*
*Department of Chemistry, Pohang University of Science and
Technology (POSTECH), San-31 Hyojadong, Pohang 790-784, Korea, Email: mjkim
postech.ac.kr,
pjwpostech.ac.kr
M.-J. Kim, Y. K. Choi, S. Kim, D. Kim, K. Han, S.-B. Ko, J. Park, Org. Lett., 2008, 10, 1295-1298.
DOI: 10.1021/ol800163z (free Supporting Information)
Abstract
A practical procedure has been developed for the dynamic kinetic resolution of 1,2-diarylethanols using a highly enantioselective lipase from Pseudomonas stutzeri as the resolution catalyst and a ruthenium complex as the racemization catalyst. Various 1,2-diarylethanols have been efficiently resolved to provide their acetyl derivatives with good yields and high enantiomeric excesses.
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Key Words
kinetic resolution of alcohols
ID: J54-Y2008-0800
