Room-Temperature Suzuki-Miyaura Couplings in Water Facilitated by Nonionic Amphiphiles
Bruce H. Lipshutz,* Tue B. Petersen and Alexander R. Abela
*Department of Chemistry & Biochemistry, University of
California, Santa Barbara, California 93106, Email: lipshutz
chem.ucsb.edu
B. H. Lipshutz, T. B. Petersen, A. R. Abela, Org. Lett., 2008, 10, 1333-1336.
DOI: 10.1021/ol702714y (free Supporting Information)
Abstract
Use of a dilute aqueous solution of a nonionic amphiphile allows efficient Suzuki-Miyaura cross-couplings of arylboronic acids with a broad range of aryl halides and pseudohalides, including sterically hindered and lipophilic substrates, in most cases at room temperature.
see article for more examples
Heck Couplings at Room Temperature in Nanometer Aqueous Micelles
B. H. Lipshutz, B. R. Taft, Org. Lett., 2008, 10, 1329-1332.
Key Words
Suzuki Coupling, Green Chemistry
ID: J54-Y2008-0910
