Organic Chemistry Portal

Abstracts

Search:

Conversion of N-Acyl Amino Acids into Imides via Oxidative Decarboxylation Induced by Ag+/Cu2+/S2O82- in Water

Wenhua Huang*, Meiling Wang, Hong Yue

*Department of Chemistry, Tianjin University, Tianjin 300072, P. R. of China, Email: huangwhtju.edu.cn

W. Huang, M. Wang, H. Yue, Synthesis, 2008, 1342-1344.

DOI: 10.1055/s-2008-1072563


Abstract

N-Acyl amino acids can be converted by oxidative decarboxylation induced by Ag+/Cu2+/S2O82- at room temperature in water into imides in good yields. Both N-benzoylvaline and N-benzoylleucine gave N-formylbenzamide, which possibly results from oxidative cleavage of an enamide intermediate.

see article for more examples



Key Words

oxidative decarboxylation, silver, copper, imides, amino acids, ammonium peroxydisulfate


ID: J66-Y2008-1110