Suzuki-Miyaura Cross-Coupling of Potassium Trifluoroboratohomoenolates
Gary A. Molander and Daniel E. Petrillo
*Roy and Diana A. Vagelos Laboratories, Department of
Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, Email:
gmolandr
sas.upenn.edu
G. A. Molander, D. E. Petrillo, Org. Lett., 2008, 10, 1795-1798.
DOI: 10.1021/ol800357c (free Supporting Information)
Abstract
Ketone-, ester-, and amide-containing potassium trifluoroboratohomoenolates were prepared in good yields from the corresponding unsaturated carbonyl compounds. They are effective coupling partners in the Suzuki-Miyaura reaction with various electrophiles including electron-rich and electron-poor aryl bromides and -chlorides.
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Key Words
Suzuki Coupling, Arylation, Alkyltrifluoroborates
ID: J54-Y2008-1200
