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Palladium-Catalyzed Cross-Coupling Reaction of Tricyclopropylbismuth with Aryl Halides and Triflates

Alexandre Gagnon*, Martin Duplessis, Pamela Alsabeh and Francis Barabé

*Boehringer Ingelheim Canada Ltd., Research and Development, 2100 Cunard Street, Laval, Québec, Canada H7S 2G5, Email: agagnonlav.boehringer-ingelheim.com

A. Gagnon, M. Duplessis, P. Alsabeh, F. Barabé, J. Org. Chem., 2008, 73, 3452-3459.

DOI: 10.1021/jo702377h (free Supporting Information)


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Abstract

The palladium-catalyzed cross-coupling reaction of tricyclopropylbismuth with aryl and heterocyclic halides and triflates tolerates numerous functional groups and does not require anhydrous conditions. The method was successfully extended to the cross-coupling of triethylbismuth.

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Key Words

Cyclopropanes, Arenes


ID: J42-Y2008-1220