Biphenylene-Substituted Ruthenocenylphosphine for Suzuki-Miyaura Coupling of Aryl Chlorides
Takashi Hoshi*, Taichi Nakazawa, Ippei Saitoh, Ayako Mori, Toshio Suzuki, Jun-ichi Sakai and Hisahiro Hagiwara*
*Faculty of Engineering and Graduate School of Science and Technology, Niigata University, 8050, 2-Nocho, Ikarashi, Nishi-ku, Niigata 950-2181, Japan, Email: hoshigs.niigata-u.ac.jp, hagiwarags.niigata-u.ac.jp
T. Hoshi, T. Nakazawa, I. Saitoh, Y. Mori, T. Suzuki, J.-i. Sakai, H. Hagiwara, S. Akai, Org. Lett., 2008, 10, 2063-2066.
DOI: 10.1021/ol800567q
Abstract
Biphenylene-substituted di-tert-butylruthenocenylphosphine (R-Phos) showed high activity as a supporting ligand in palladium-catalyzed Suzuki-Miyaura reactions of aryl chlorides with arylboronic acids. Substrate combinations even for the construction of highly hindered tetra-ortho-substituted biaryls can be achieved in good to excellent yields with low catalyst loadings.
see article for more examples
T. Hoshi, T. Honma, A. Mori, M. Konishi, T. Sato, H. Hagiwara, T. Suzuki, J. Org. Chem., 2013, 78, 11513-11524.
Key Words
ID: J54-Y2008-1320