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Iridium-Catalyzed Enantioselective Hydrogenation of α,β-Unsaturated Carboxylic Acids

Shen Li, Shou-Fei Zhu, Can-Ming Zhang, Song Song and Qi-Lin Zhou

*State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China, Email: qlzhounankai.edu.cn

S. Li, S.-F. Zhu, C.-M. Zhang, S. Song, Q.-L. Zhou, J. Am. Chem. Soc., 2008, 130, 8584-8585.

DOI: 10.1021/ja802399v (free Supporting Information)


Abstract

A highly efficient iridium-catalyzed hydrogenation of α,β-unsaturated carboxylic acids in the presence of chiral spiro-phosphino-oxazoline ligands affords α-substituted chiral carboxylic acids in exceptionally high enantioselectivities and reactivities.

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Ruthenium complexes of rigid diphosphane ligands with large dihedral angles are highly efficient catalysts for the asymmetric hydrogenation of α,β-unsaturated carboxylic acids

X. Cheng, Q. Zhang, J.-H. Xie, L.-X. Wang, Q.-L. Zhou, Angew. Chem. Int. Ed., 2005, 44, 1118-1121.

Iridium-Catalyzed Asymmetric Hydrogenation of Cyclic Enamines

G.-H. Hou, J.-H. Xie, P.-C. Yan, Q.-L. Zhou, J. Am. Chem. Soc., 2008, 131, 1366-1367.


Key Words

reduction of α,β-unsaturated carboxylic acids, hydrogen


ID: J48-Y2008-1840