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Iridium-Catalyzed Enantioselective Hydrogenation of α,β-Unsaturated Carboxylic Acids

Shen Li, Shou-Fei Zhu, Can-Ming Zhang, Song Song and Qi-Lin Zhou

*State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China, Email:

S. Li, S.-F. Zhu, C.-M. Zhang, S. Song, Q.-L. Zhou, J. Am. Chem. Soc., 2008, 130, 8584-8585.

DOI: 10.1021/ja802399v (free Supporting Information)


A highly efficient iridium-catalyzed hydrogenation of α,β-unsaturated carboxylic acids in the presence of chiral spiro-phosphino-oxazoline ligands affords α-substituted chiral carboxylic acids in exceptionally high enantioselectivities and reactivities.

see article for more examples

Ruthenium complexes of rigid diphosphane ligands with large dihedral angles are highly efficient catalysts for the asymmetric hydrogenation of α,β-unsaturated carboxylic acids

X. Cheng, Q. Zhang, J.-H. Xie, L.-X. Wang, Q.-L. Zhou, Angew. Chem. Int. Ed., 2005, 44, 1118-1121.

Iridium-Catalyzed Asymmetric Hydrogenation of Cyclic Enamines

G.-H. Hou, J.-H. Xie, P.-C. Yan, Q.-L. Zhou, J. Am. Chem. Soc., 2008, 131, 1366-1367.

Key Words

reduction of α,β-unsaturated carboxylic acids, hydrogen

ID: J48-Y2008-1840