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Using Toluates as Simple and Versatile Radical Precursors

Kevin Lam and István E. Markó

*Département de Chimie, Bâtiment Lavoisier, Université catholique de Louvain, Place Louis Pasteur, 1, B-1348 Louvain-la-Neuve, Belgium, Email: istvan.markouclouvain.be

K. Lam, I. E. Markó, Org. Lett., 2008, 10, 2919-2922.

DOI: 10.1021/ol800944p (free Supporting Information)



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Abstract

A new, easy and versatile methodology for the deoxygenation of alcohols via the corresponding toluates offers a broad scope using simple and commercially available reagents such as toluolyl chloride and samarium(II) iodide. In addition, this methodology is also useful for radical cyclizations directly from toluate precursors.

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Notes

Some benefits of the method:

Kevin Lam, December 22, 2009


Organic electrosynthesis using toluates as simple and versatile radical precursors

K. Lam, I. E. Markó, Chem. Commun., 2009, 95-97.


Key Words

deoxygenations, samarium diiodide


ID: J54-Y2008-1990