Direct Acylation of Aryl Bromides with Aldehydes by Palladium Catalysis
Jiwu Ruan, Ourida Saidi, Jonathan A. Iggo and Jianliang Xiao*
*Department of Chemistry, Liverpool Centre for Materials and Catalysis, University of Liverpool, Liverpool L69 7ZD, U.K., Email: j.xiaoliv.ac.uk
J. Ruan, O. Saidi, J. A. Iggo, J. Xiao, J. Am. Chem. Soc., 2008, 130, 10510-10511.
DOI: 10.1021/ja804351z (free Supporting Information)
A direct acylation of aryl bromides with aldehydes involves palladium-amine cooperative catalysis, affording synthetically important alkyl aryl ketones in good yields in a straightforward manner, and broadening the scope of metal-catalyzed coupling reactions.
see article for more examples
proposed reaction pathway