Rapid and Efficient Pd-Catalyzed Sonogashira Coupling of Aryl Chlorides
He Huang, Hong Liu*, Hualiang Jiang and Kaixian Chen
*Drug Discovery and Design Centre, State Key Laboratory of
Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for
Biological Sciences, and Graduate School, Chinese Academy of Sciences, 555
Zuchongzhi Road, Shanghai 201203, China, Email: hliu
mail.shcnc.ac.cn
H. Huang, H. Liu, H. Jiang, K. Chen, J. Org. Chem., 2008, 73, 6037-6040.
DOI: 10.1021/jo800994f (free Supporting Information)
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Abstract
An efficient and effective microwave-assisted cross-coupling of terminal alkynes with various aryl chlorides including sterically hindered substrates proceeds fast and generally gives coupled products in very good yields. The conditions were extended successfully to Suzuki coupling, Buchwald-Hartwig amination, and the Heck coupling of aryl chlorides.
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Key Words
Sonogashira Coupling, Microwave Synthesis
ID: J42-Y2008-2180
