A Facile Synthesis of N-Carbamoylamino Acids
Andrey V. Bogolubsky, Sergey V. Ryabukhin*, Gennadiy G. Pakhomov, Eugeniy N. Ostapchuk, Alexander N. Shivanyuk, Andrey A. Tolmachev
*National Taras Shevchenko University, 62 Volodymyrska st.,
01033 Kyiv-33, Ukraine, Email: ryabukhin
mail.enamine.net
A. V. Bogolubsky, S. V. Ryabukhin, G. G. Pakhomov, E. N. Ostapchuk, A. N. Shivanyuk, A. A. Tolmachev, Synlett, 2008, 2279-2282.
DOI: 10.1055/s-2008-1078017 (free Supporting Information)
Abstract
Structurally and functionally diverse N-carbamoylamino acids were obtained through the alkylation of monosubstituted parabanic acids followed by hydrolysis of the intermediate products in very good yields and excellent purity.
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Key Words
monosubstituted parabanic acids, α-amino acids, urea derivatives, N-carbamoylamino acids, hydrolysis, alkylation, sonochemistry
ID: J60-Y2008-2410
