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Copper(I)-Catalyzed Three-Component Coupling Leading to an Efficient ­Synthesis of β,γ-Alkynyl α-Amino Acid Derivatives

Zhihui Shao, Albert S. C. Chan*

*Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hong Kong, P. R. of China, Email: bcachanpolyu.edu.hk

Z. Shao, A. S. C. Chan, Synthesis, 2008, 2868-2870.

DOI: 10.1055/s-2008-1067234


Abstract

A copper(I)-catalyzed direct three-component coupling of ethyl glyoxylate, p-anisidine, and terminal alkynes provides β,γ-alkynyl α-amino acid derivatives in good yields.

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Key Words

copper, catalysis, multicomponent reactions, β,γ-alkynyl α-amino acids, propargyl amines, α-amino acids


ID: J66-Y2008-2470