Nickel-Catalyzed Asymmetric Cross-Couplings of Racemic Propargylic Halides with Arylzinc Reagents
Sean W. Smith and Gregory C. Fu*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: gcfmit.edu
S. W. Smith, G. C. Fu, J. Am. Chem. Soc., 2008, 130, 12645-12647.
DOI: 10.1021/ja805165y (free Supporting Information)
A catalytic asymmetric Negishi cross-coupling of racemic secondary propargylic halides with arylzinc reagents has been developed using commerically available catalyst components (NiCl2·glyme and pybox as ligand).
see article for more examples
S. Son, G. C. Fu, J. Am. Chem. Soc., 2008, 130, 2756-2757.