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Nonracemic Diarylmethanols From CuH-Catalyzed Hydrosilylation of Diaryl Ketones

Ching-Tien Lee and Bruce H. Lipshutz*

*Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, Email: lipshutzchem.ucsb.edu

C.-T. Lee, B. H. Lipshutz, Org. Lett., 2008, 10, 4187-4190.

DOI: 10.1021/ol801590j (free Supporting Information)


Abstract

The use of (R)-(−)-(DTBM-SEGPHOS)CuH effects a highly enantioselective 1,2-hydrosilylation of prochiral diaryl ketones to yield nonracemic diarylmethanols in excellent yields.

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Copper(I) Hydride-Catalyzed Asymmetric Hydrosilylation of Heteroaromatic Ketones

B. H. Lipshutz, A. Lower, K. Noson, Org. Lett., 2002, 4, 4045-4048.


Key Words

Copper Hydride, PMHS, Reduction of Ketones


ID: J54-Y2008-2720